Most of the absorption of an oral drug occurs in
An important mechanism for transport of very large molecules across membranes
Sustained released preparation of an oral drug is most likely absorbed in
Alkaline environment in the kidneys favors
Which of the following statements is correct?
Biotransformation usually results in a product that is
CYP450 enzyme responsible for metabolizing approximately 50% of drugs
In the elderly, the liver's capacity for metabolism through the CYP450 enzyme system is reduced by
Glucuronidation is related to
Which of the following drugs are excreted in bile?
Dose administered divided by the Clearance denotes
Dose administered divided by the resulting Plasma concentration denotes
Volume of distribution (Vd) of a drug divided by the Clearance denotes
Rate of elimination divided by the Plasma concentration denotes
Which of the following drug follows zero-order kinetics when administered in higher doses?
Which of the following statements is incorrect?
A drug that binds to its receptor but produces a smaller effect at full dosage is
An example for Ionotropic receptors
GABA-A receptors are ligand-gated ion channels, which open to allow ______ ions to enter the cell.
An example for G protein–coupled receptors
An example for Nuclear receptors
An example for Kinase-linked receptors
Following drugs have narrowest margin of safety except
A narrow therapeutic index means that the
Uncommon or slowly developing adverse drug effects are usually detected in
Which of the following drug inhibits secretion of penicillin by the renal tubules?
To avoid bias, clinical trials should be
Placebos in clinical trials are used in
Which of the following statement is incorrect?
If Drug A produces same effect as Drug B, which of the following best describes Drug A?
If 5mg of Drug A produces same effect as 50mg of Drug B, which of the following statements is correct?
If 5mg of Drug A produces greater therapeutic effect than Drug B at any dose, which of the following statements is correct?
In the presence of Drug B, a higher concentration of Drug A is required to elicit full therapeutic effect. Drug B by itself has no effect. Which of the following statements is correct?
In the presence of Drug B, a higher concentration of Drug A is required to elicit full therapeutic effect. Drug B by itself has a smaller effect than does Drug A even at the highest dose. Which of the following statements is correct?
In the presence of Drug B, Drug A is less efficacious regardless of the dose. Drug B by itself has no effect even at the highest dose. Which of the following statements is correct?
An example of competitive antagonism
