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Anxiolytics and sedatives

by drdasaraju
April 28, 2022

All the following are true regarding selective serotonin reuptake inhibitors (SSRIs), except

Effective for treating generalised anxiety disorder

Take days to weeks to develop anxiolytic effects

Does not reduce depression associated with anxiety

Not associated with dependence and tolerance

None

All the following are true regarding benzodiazepines, except

Can be co-administered during stabilisation of a patient on an SSRI

Used to treat acute anxiety

Cause retrograde amnesia

Act allosterically to increase the affinity of GABA for the receptor

None

All the following benzodiazepines can be used as anticonvulsants, except

Diazepam

Alprazolam

Lorazepam

Clonazepam

None

All the following are true regarding zolpidem, except

Inhibitors of CYP3A4 increases its half-life

Bind selectively to a subgroup of GABA-A receptors

Is a benzodiazepine

Ultrashort acting hypnotic drug

None

All the following are true regarding buspirone, except

Effective in the treatment of severe anxiety states

Does not suppress the benzodiazepine withdrawal syndrome

Partial agonist at 5-HT1A receptors

Not associated with sedation

None

All the following are true regarding flumazenil, except

Competitive antagonist at GABA-A receptors

Used to reverse the CNS depressant effects of benzodiazepines

Given intravenously

Not associated with sedation

None

All the following are true regarding ramelteon, except

Has agonistic acivity at melatonin receptors in the suprachiasmatic nuclei of the brain

Inhibitors of cytochrome P450 increases its half-life

Approved for non-24-hour sleep-wake disorder

Associated with rebound insomnia

None

Time's up

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