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Anxiolytics and sedatives

by drdasaraju
April 28, 2022

All the following are true regarding selective serotonin reuptake inhibitors (SSRIs), except

Does not reduce depression associated with anxiety

Effective for treating generalised anxiety disorder

Not associated with dependence and tolerance

Take days to weeks to develop anxiolytic effects

None

All the following are true regarding benzodiazepines, except

Cause retrograde amnesia

Can be co-administered during stabilisation of a patient on an SSRI

Used to treat acute anxiety

Act allosterically to increase the affinity of GABA for the receptor

None

All the following benzodiazepines can be used as anticonvulsants, except

Lorazepam

Clonazepam

Alprazolam

Diazepam

None

All the following are true regarding zolpidem, except

Bind selectively to a subgroup of GABA-A receptors

Inhibitors of CYP3A4 increases its half-life

Ultrashort acting hypnotic drug

Is a benzodiazepine

None

All the following are true regarding buspirone, except

Partial agonist at 5-HT1A receptors

Not associated with sedation

Effective in the treatment of severe anxiety states

Does not suppress the benzodiazepine withdrawal syndrome

None

All the following are true regarding flumazenil, except

Not associated with sedation

Given intravenously

Used to reverse the CNS depressant effects of benzodiazepines

Competitive antagonist at GABA-A receptors

None

All the following are true regarding ramelteon, except

Approved for non-24-hour sleep-wake disorder

Inhibitors of cytochrome P450 increases its half-life

Associated with rebound insomnia

Has agonistic acivity at melatonin receptors in the suprachiasmatic nuclei of the brain

None

Time's up

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