Anticoagulants & Fibrinolytics

All the following are anticoagulants, except

Streptokinase

Apixaban

Heparin

Warfarin

None

All the following are true regarding heparin, except

Monitoring is not needed with low molecular-weight heparins

Unfractionated heparin is used for patients with impaired renal function

Inactivates Xa and thrombin by potentiating antithrombin III

Administered as intramuscular injection

None

All the following are true regarding warfarin, except

Decrease maturation of clotting factors by inhibiting vitamin K epoxide reductase

Anticoagulant effect is monitored by measuring prothrombin time (PT)

Takes 5 to 7 days to show anticoagulant effect

Can be given to pregnant women from second trimester onwards

None

All the following are true regarding apixaban, except

Direct inhibitor of thrombin

Administered orally

Monitoring is not required for its anticoagulant effects

Faster onset of action compared to warfarin

None

All the following are true regarding fibrinolytcs, except

Reduces mortality in acute myocardial infarction or stroke

Recombinant preparations preferably bind to plasma plasminogen

Streptokinase is an example

Bleeding due to fibrinolytics can be treated with tranexamic acid

None

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