Hypolipidaemics

All the following are class of hypolipidaemic agents, except

Cholesterol absorption inhibitors

HMG-CoA reductase inhibitors

PPARα receptor blockers

Bile acid-binding resins

All the following are true regarding HMG-CoA reductase inhibitors, except

Can be safely given in pregnancy

Associated with myalgia in renal failure patients

Increase expression of low-density lipoprotein (LDL) receptors on hepatocytes

Atorvastatin is an example

All the following are true regarding PPARα receptor activators, except

Fenofibrate is an example

Combined with statins decrease the risk of rhabdomyolysis

Very effective in treating hypertriglyceridaemia

Increase activity of lipoprotein lipase

All the following are true regarding cholesterol absorption inhibitors, except

Colesevelam is an example

Does not interfere with the absorption of fat-soluble vitamins

Combined with statins in severe drug-resistant dyslipidaemias

Associated with diarrhoea

All the following are true regarding bile acid-binding resins, except

First-line drugs in the management of dyslipidaemia

Can be used to treat pruritus in patients with partial biliary obstruction

Interferes with the absorption of fat-soluble vitamins

Cause a transient increase in triglycerides

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