Drugs for RA

All the following are antirheumatoid agents, except

Tofacitinib

Etanercept

Denosumab

Methotrexate

All the following are true regarding DMARD therapy in rheumatoid arthritis, except

Initiated as soon as a definite diagnosis is made

Concomitant NSAID or glucocorticoid therapy is recommended

Produces disease remission

Clinical effects are rapid in onset

The immunosuppressive effect of methotrexate is a result of its inhibition of

Phospholipase A2

Microtubule function

Dihydrofolate reductase

Leukocyte migration

All the following are adverse effects of methotrexate, except

Bone marrow depression

Posterior subcapsular cataracts

Renal insufficiency

Hepatic cirrhosis

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