Drugs for RA

All the following are antirheumatoid agents, except

Denosumab

Tofacitinib

Etanercept

Methotrexate

All the following are true regarding DMARD therapy in rheumatoid arthritis, except

Concomitant NSAID or glucocorticoid therapy is recommended

Clinical effects are rapid in onset

Produces disease remission

Initiated as soon as a definite diagnosis is made

The immunosuppressive effect of methotrexate is a result of its inhibition of

Dihydrofolate reductase

Phospholipase A2

Leukocyte migration

Microtubule function

All the following are adverse effects of methotrexate, except

Posterior subcapsular cataracts

Renal insufficiency

Bone marrow depression

Hepatic cirrhosis

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