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Antidepressants

by drdasaraju
April 28, 2022

All the following are class of antidepressant drugs, except

Monoamine oxidase inhibitors

Selective serotonin reuptake inhibitors

Noradrenaline reuptake inhibitors

α2 adrenoceptor agonists

All the following are true regarding selective serotonin reuptake inhibitors (SSRIs), except

Risk of cardiotoxicity is less compared to tricyclic antidepressants

Escitalopram is an example

Not recommended for treating depression in children <18 yrs of age

Can be used in combination with monoamine oxidase inhibitors

All the following are true regarding tricyclic antidepressants (TCAs), except

Can be used to treat neuropathic pain

Interact with histaminic, adrenergic and muscarinic receptors

Venlafaxine is an example

Higher risk of ventricular dysrhythmias

All the following are true regarding monoamine oxidase inhibitors (MAOIs), except

Indicated in major depression unresponsive to other drugs

‘Cheese reaction’ is less severe and shorter lasting with reversible MAOIs

Moclobemide is an example of non-selective MAO inhibitor

Orthostatic hypotension is a common adverse effect leading to their discontinuation

All the following are true regarding duloxetine, except

Has relatively fewer CYP450 interactions than the SSRIs

Inhibits uptake of noradrenaline and 5-HT

Can be used to treat urinary incontinence

Commonly associated with hepatotoxicity

All the following are true regarding bupropion, except

Inhibits uptake of noradrenaline and dopamine

Not effective in the treatment of the anxiety disorders

Can be used to treat nicotine dependence

Can be used in patients taking MAOIs

All the following are true regarding mirtazapine, except

Substrate for several CYP450 enzymes

Higher risk of sexual dysfunction compared to SSRIs

Causes sedation due to its H1-receptor blocking action

Acts by blocking α2 adrenoceptors and 5-HT2C receptors

Time is Up!

Time's up

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