Anticancer drugs

All the following are true regarding cancer cells, except

Most anticancer drugs target cancer cells without affecting normal healthy cells

Cancer arises due to inactivation of tumour suppressor genes

Cancer cells have uncontrolled proliferation due to changes in apoptotic pathways

Cancer cells have the ability to metastasize

All the following are true regarding mechanism of action of anticancer drugs, except

Block metabolic pathways involved in DNA synthesis

Activate growth factor receptor signal transduction

Prevent cell replication by forming covalent bonds with DNA

Affect microtubule function

All the following are true regarding alkylating agents, except

Cyclophosphamide is an example of alkylating agents

Myelosuppression is an important adverse effect associated with these agents

Cell-cycle specific agents

Cross-link DNA resulting in defective replication and chain termination

All the following are true regarding cell-cycle specific agents, except

Analogues of purines and pyrimidines form fraudulent nucleotides

Vinca alkaloids inhibit mitosis at M-phase by binding to tubulin

Folate antagonists are effective against S-phase of cell cycle

Taxanes inhibit mitosis by binding to topoisomerase enzymes

All the following drugs inhibit topoisomerase enzyme, except

Irinotecan

Etoposide

Mitoxantrone

Bleomycin

All the following kinase inhibitors are used in cancer management, except

Imatinib

Sorafenib

Tofacitinib

Erlotinib

All the following monoclonal antibodies are used in cancer management, except

Nivolumab

Omalizumab

Trastuzumab

Rituximab

All the following are hormone synthesis inhibitors used in cancer management, except

Exemastine

Abiraterone

Bicalutamide

Finasteride

All the following are hormone receptor antagonists used in cancer management, except

Fulvestrant

Tamoxifen

Bicalutamide

Leuprorelin

All the following are true regarding indications of anticancer drugs, except

Nitrosoureas are very effective against brain tumors

Cisplatin is the treatment of choice for germ cell tumours

Cell cycle specific drugs are ineffective against lymphomas

Imatinib is standard first-line therapy in chronic myelogenous leukemia

All the following are true regarding adverse effects of anticancer drugs, except

Cardiotoxicity is associated with anthracyclines

Secondary leukemias can result from procarbazine

Cyclophosphamide causes hemorrhagic cystitis

Bleomycin causes severe myelosuppression

All the following are true regarding management of adverse effects of anticancer drugs, except

NK-1 receptor antagonists are ineffective against cisplatin induced nausea and vomiting

Leucovorin decreases methotrexate toxicity

Dexrazoxane chelates iron toxicity due to anthracyclines

Hemorrhagic cystitis due to cyclophosphamide is treated with mesna

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