Anticancer drugs – Cytotoxic drugs

1.

All the following are true regarding cancer cells, except

Cancer cells have the ability to metastasize

Cancer arises due to inactivation of tumour suppressor genes

Most anticancer drugs target cancer cells without affecting normal healthy cells

Cancer cells have uncontrolled proliferation due to changes in apoptotic pathways

2.

All the following are true regarding alkylating agents, except

Cyclophosphamide is an example of alkylating agents

Cell-cycle specific agents

Myelosuppression is an important adverse effect associated with these agents

Cross-link DNA resulting in defective replication and chain termination

3.

All the following are true regarding mechanism of action of anticancer drugs, except

Block metabolic pathways involved in DNA synthesis

Affect microtubule function

Prevent cell replication by forming covalent bonds with DNA

Activate growth factor receptor signal transduction

4.

All the following drugs inhibit topoisomerase enzyme, except

Etoposide

Mitoxantrone

Bleomycin

Irinotecan

5.

All the following are true regarding cell-cycle specific agents, except

Folate antagonists are effective against S-phase of cell cycle

Analogues of purines and pyrimidines form fraudulent nucleotides

Vinca alkaloids inhibit mitosis at M-phase by binding to tubulin

Taxanes inhibit mitosis by binding to topoisomerase enzymes

6.

All the following are true regarding adverse effects of anticancer drugs, except

Cyclophosphamide causes hemorrhagic cystitis

Bleomycin causes severe myelosuppression

Cardiotoxicity is associated with anthracyclines

Secondary leukemias can result from procarbazine

7.

All the following are true regarding management of adverse effects of anticancer drugs, except

Dexrazoxane chelates iron toxicity due to anthracyclines

Hemorrhagic cystitis due to cyclophosphamide is treated with mesna

Leucovorin decreases methotrexate toxicity

NK-1 receptor antagonists are ineffective against cisplatin induced nausea and vomiting

8.

All the following are true regarding indications of anticancer drugs, except

Cisplatin is the treatment of choice for germ cell tumours

Imatinib is standard first-line therapy in chronic myelogenous leukemia

Cell cycle specific drugs are ineffective against lymphomas

Nitrosoureas are very effective against brain tumors

Anticancer drugs – Cytotoxic drugs

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