Anticancer drugs

All the following are first-line drugs for tuberculosis, except

Streptomycin

Ethambutol

Isoniazid

Rifampicin

All the following are true regarding isoniazid, except

Inhibits cell wall synthesis by binding to mycolic acids

Therapeutic response is good in slow acetylators

Pyridoxine deficiency increases risk of neurotoxicity

Not effective against intracellular organisms

All the following are true regarding rifampicin, except

Gives orange discoloration to body secretions

Potent inhibitor of CYP450 enzymes

Inhibits mycobacterial DNA-dependent RNA polymerase

Effective against intracellular organisms

All the following are true regarding ethambutol, except

Colour vision should be monitored before and during prolonged treatment

Acts by inhibiting mycobacterial cell wall synthesis

Has bactericidal effect

Associated with optic neuritis

All the following are true regarding pyrazinamide, except

Effective against intracellular organisms

Acts by inhibiting mycobacterial fatty acid synthesis

Develops cross-resistance with isoniazid

Liver function should be assessed before treatment

All the following are second-line drugs for tuberculosis, except

Delamanid

Cyclosporine

Moxifloxacin

Bedaquiline

All the following are true regarding drug resistant tuberculosis (DR-TB), except

DR-TB regimens require a longer course compared to the treatment for drug susceptible TB

Bedaquiline should not be used more than 4 months in patients with MDR-TB

Could be due to inadequate or poorly administered treatment regimen

Kanamycin and capreomycin are no longer part of MDR-TB regimens

All the following drugs are used for leprosy, except

Ethionamide

Clofazimine

Dapsone

Rifampicin

All the following are true regarding leprosy treatment, except

Combination therapy is recommended to prevent the emergence of resistance

Clofazimine is indicated in tuberculoid leprosy

Duration of therapy differs with the type of leprosy

Lepromatous leprosy is treated for at least 2 years

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