Anticancer drugs – Sample MCQs

1.

All the following drugs inhibit topoisomerase enzyme, except

Bleomycin

Mitoxantrone

Etoposide

Irinotecan

2.

All the following are true regarding cell-cycle specific agents, except

Folate antagonists are effective against S-phase of cell cycle

Taxanes inhibit mitosis by binding to topoisomerase enzymes

Vinca alkaloids inhibit mitosis at M-phase by binding to tubulin

Analogues of purines and pyrimidines form fraudulent nucleotides

3.

All the following are true regarding cancer cells, except

Most anticancer drugs target cancer cells without affecting normal healthy cells

Cancer cells have the ability to metastasize

Cancer arises due to inactivation of tumour suppressor genes

Cancer cells have uncontrolled proliferation due to changes in apoptotic pathways

4.

All the following monoclonal antibodies are used in cancer management, except

Rituximab

Omalizumab

Nivolumab

Trastuzumab

5.

All the following are true regarding alkylating agents, except

Cell-cycle specific agents

Cross-link DNA resulting in defective replication and chain termination

Cyclophosphamide is an example of alkylating agents

Myelosuppression is an important adverse effect associated with these agents

6.

All the following are hormone receptor antagonists used in cancer management, except

Tamoxifen

Bicalutamide

Leuprorelin

Fulvestrant

7.

All the following are true regarding adverse effects of anticancer drugs, except

Cyclophosphamide causes hemorrhagic cystitis

Bleomycin causes severe myelosuppression

Secondary leukemias can result from procarbazine

Cardiotoxicity is associated with anthracyclines

8.

All the following kinase inhibitors are used in cancer management, except

Erlotinib

Sorafenib

Tofacitinib

Imatinib

9.

All the following are true regarding mechanism of action of anticancer drugs, except

Block metabolic pathways involved in DNA synthesis

Prevent cell replication by forming covalent bonds with DNA

Activate growth factor receptor signal transduction

Affect microtubule function

10.

All the following are true regarding management of adverse effects of anticancer drugs, except

Hemorrhagic cystitis due to cyclophosphamide is treated with mesna

NK-1 receptor antagonists are ineffective against cisplatin induced nausea and vomiting

Leucovorin decreases methotrexate toxicity

Dexrazoxane chelates iron toxicity due to anthracyclines

11.

All the following are true regarding indications of anticancer drugs, except

Imatinib is standard first-line therapy in chronic myelogenous leukemia

Cisplatin is the treatment of choice for germ cell tumours

Cell cycle specific drugs are ineffective against lymphomas

Nitrosoureas are very effective against brain tumors

12.

All the following are hormone synthesis inhibitors used in cancer management, except

Finasteride

Exemastine

Abiraterone

Bicalutamide

Anticancer drugs – Sample MCQs

Leave a Reply Cancel reply