Other Antimicrobials – Sample MCQs

All the following are true regarding antiretroviral therapy, except

Antiretroviral drugs cannot eradicate the virus from the human body

Dolutegravir-containing regimen is the preferred first-line treatment for HIV-positive patients

All persons diagnosed with HIV infection should be initiated on ART regardless of CD4 count

Dolutegravir is not recommended in HIV patients taking rifampicin-based anti-TB regimen

None

All the following are true regarding pegylated interferon-α, except

Augment proliferation and survival of cytotoxic T cells

Given subcutaneously

Can be used in children and pregnant women

Effective against both hepatitis B and C virus infections

None

Antihelminthic drugs act by one of the following mechanisms of action, except

Interfering glucose uptake

Stabilization of microtubules

Unmasking novel antigens

Paralyzing the parasite

None

Administration of intravenous zidovudine to prevent vertical transmission of HIV infection from mother to fetus is not required if viral load is

Less than or equal to 100 copies/mL

Less than or equal to 200 copies/mL

Less than or equal to 150 copies/mL

Less than or equal to 50 copies/mL

None

Drug indicated in varicella-zoster virus (VZV) infection is

Remdesivir

Oseltamivir

Sofosbuvir

Acyclovir

None

All the following are true regarding azoles, except

Have broad spectrum of antifungal activity

Potent inhibitors of CYP450 enzyme system

Fungicidal agents

Available as oral, parenteral and topical preparations

None

All the following drugs are effective against treatment of amoebiasis, except

Metronidazole

Suramin

Diloxanide

Paromomycin

None

Which of the following drug is effective in eradicating P. vivax and P. ovale parasites in the liver?

Artemisine

Lumefantrine

Chloroquine

Primaquine

None

All the following are true regarding acyclovir, except

Associated with irreversible renal toxicity

Available as oral, parenteral and topical preparations

Inhibit viral DNA polymerase

Guanosine derivative

None

10.

All the following are true regarding management of neurocysticercosis, except

Albendazole is the preferred drug due to its improved penetration into the subarachnoid space

Praziquantel can be used as an alternative to albendazole

Corticosteroid decreases the bioavailability of albendazole

Albendazole combined with praziquantel improves efficacy in patients with multiple brain cysts

None

11.

All the following are true regarding remdesivir, except

Blocks the SARS-CoV-2 RNA-dependent RNA polymerase enzyme

Given 200mg as bolus dose intravenously

Recommended for patients with mild to moderate COVID-19 symptoms

Associated with increase in ALT levels

None

12.

All the following are true regarding oseltamivir, except

Inhibits neuraminidase enzyme and prevent viral escape from infected cells

Available as oral and parenteral formulations

Effective against Influenza A only

Associated with gastrointestinal upset

None

13.

All the following are true regarding metronidazole, except

Kill microorganisms by forming reduced cytotoxic compounds

Should not be given to pregnant women

Has excellent activity against aerobic and anaerobic bacteria

Potential to cause disulfiram-like reaction with alcohol

None

14.

All the following are true regarding post-exposure prophylaxis (PEP) of HIV, except

Zidovudine containing regimen is preferred in children if Hb <9 g/dl

More effective when given within 72 hours after exposure

Tenofovir containing regimen is preferred in adults

Duration of post-exposure prophylaxis is 28 days

None

15.

All the following are true regarding amphotericin, except

Binds avidly to the cell membrane of all microorganisms including bacteria

Very effective against infections caused by Aspergillus and Candida

Belongs to a group of drugs called ‘polyenes’

Lipid-complexed preparations cause lesser side effects

None